Abstract |
Oleuropein, a phenolic compound found in abundance in olive leaves, has beneficial effects on various diseases. However, it is unknown whether an oleuropein-rich diet is efficacious against type 2 diabetic phenotypes. In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. TSOD mice were fed OPIACE at 4 weeks of age, i.e., before the TSOD mice exhibited diabetic phenotypes. We revealed that OPIACE attenuated hyperglycemia and impaired glucose tolerance in TSOD mice over the long-term (from 10 to 24 weeks of age) but had no effect on obesity. Furthermore, we demonstrated that OPIACE mildly reduced oxidative stress in TSOD mice by 26.2% and attenuated anxiety-like behavioral abnormality in aged TSOD mice. The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term.
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Authors | Kazutoshi Murotomi, Aya Umeno, Mayu Yasunaga, Mototada Shichiri, Noriko Ishida, Taisuke Koike, Toshiki Matsuo, Hiroko Abe, Yasukazu Yoshida, Yoshihiro Nakajima |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 63
Issue 30
Pg. 6715-22
(Aug 05 2015)
ISSN: 1520-5118 [Electronic] United States |
PMID | 26165358
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Iridoid Glucosides
- Iridoids
- oleuropein
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Type 2
(diet therapy, metabolism)
- Diet
- Disease Models, Animal
- Glucose Tolerance Test
- Humans
- Hyperglycemia
(diet therapy)
- Iridoid Glucosides
- Iridoids
(metabolism)
- Male
- Mice
- Mice, Obese
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