Abstract | BACKGROUND: AIMS: METHOD: NMRI mice were treated with anakinra (IL-1Ra) daily for 7 days before intravenous inoculation with S. aureus strain Newman in both arthritogenic and lethal doses. The clinical course of septic arthritis, histopathological and radiological changes of the joints, as well as the mortality were compared between IL-1Ra treated and control groups. RESULTS:
IL-1Ra treated mice developed more frequent and severe clinical septic arthritis. Also, the frequency of polyarthritis was significantly higher in the mice receiving IL-1Ra therapy. In line with the data from clinical arthritis, both histological and radiological signs of septic arthritis were more pronounced in IL-1Ra treated group compared to controls. Importantly, the mortality of IL-1Ra treated mice was significantly higher than PBS treated controls. CONCLUSION:
IL-1Ra treatment significantly aggravated S. aureus induced septic arthritis and increased the mortality in these mice.
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Authors | Abukar Ali, Manli Na, Mattias N D Svensson, Malin Magnusson, Amanda Welin, Jan-Christoph Schwarze, Majd Mohammad, Elisabet Josefsson, Rille Pullerits, Tao Jin |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 7
Pg. e0131645
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26135738
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Il1rn protein, mouse
- Interleukin 1 Receptor Antagonist Protein
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Topics |
- Animals
- Arthritis, Experimental
(drug therapy, microbiology)
- Arthritis, Infectious
(drug therapy, microbiology)
- Cytokines
(metabolism)
- Disease Models, Animal
- Female
- Inflammation
(drug therapy, metabolism)
- Interleukin 1 Receptor Antagonist Protein
(therapeutic use)
- Joints
(pathology)
- Kidney
(pathology)
- Macrophages, Peritoneal
(metabolism)
- Mice
- Sepsis
(drug therapy, microbiology)
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus
- Staphylococcus aureus
- X-Ray Microtomography
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