Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense.

Abstract

Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC50 value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones 1-3. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds 1-3 exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC50 values of 0.8, 0.7, and 0.8 μM, respectively.

• Authors: Alexander L Eaton, L Harinantenaina Rakotondraibe, Peggy J Brodie, Michael Goetz, David G I Kingston
• Journal: Journal of natural products (J Nat Prod) Vol. 78 Issue 7 Pg. 1752-5 (Jul 24 2015) ISSN: 1520-6025 [Electronic] United States
• PMID: 26132421 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Cyclohexanones

Topics

• Anacardiaceae (chemistry)
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cyclohexanones (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Inhibitory Concentration 50
• Molecular Structure
• Plant Bark (chemistry)
• Tonga