This study was set out to determine the association of serum
adiponectin and oxidative stress in newly diagnosed
type 2 diabetes patients. 106 patients with newly diagnosed
type 2 diabetes were recruited. Simultaneously scanning of the extracranial carotid arteries, common iliac arteries and femoral arteries were performed for measurement of intima media thickness (IMT) in all subjects.
Atherosclerotic plaque was defined as IMT value >1.3 mm. The serum levels of
adiponectin and 8-iso-prostaglandin F2α (8-iso-PGF2α), a marker of oxidative stress, were examined by
enzyme-linked
immunosorbent assay. Metabolic parameters were detected by clinical chemistry. According to the results, all of 106 patients with
type 2 diabetes were newly diagnosed within 12 months, and aged 60.68±4.32 years. The level of serum
adiponectin in newly diagnosed
type 2 diabetes patients was lower than that in healthy subjects. Furthermore,
type 2 diabetes patients with
atherosclerotic plaques had lower serum
adiponectin level than those without
atherosclerotic plaques. Serum 8-iso-PGF2α level in newly diagnosed
type 2 diabetes patients was higher than that in healthy subjects. Further analyses showed that serum
adiponectin level was reversely associated with serum 8-iso-PGF2α in newly diagnosed
type 2 diabetes patients. Additionally, the
atherosclerotic plaques in newly diagnosed
type 2 diabetes patients were positively correlated with total
cholesterol, but negatively correlated with serum
adiponectin level. Taken together, this study suggests that in newly diagnosed
type 2 diabetes, serum
adiponectin levels are probably associated with oxidative stress and also with the severity of
atherosclerosis.