Abstract |
Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and China National Knowledge Infrastructure databases for relevant studies that examined the G-217A polymorphism and risk of essential hypertension. Statistical analyses were carried out using Stata 12.0 to combine all relevant studies. Crude odds ratios ( ORs) with 95% confidence intervals (95%CIs) were calculated to estimate the strength of this association. A total of 2017 patients with psoriasis and 1708 controls from 7 comparative studies were included in this meta-analysis. We found a significant association between the AGT G-217A gene polymorphism and the risk of essential hypertension (AA vs GG: OR = 2.52, 95%CI = 1.68-3.78; AA vs GA: OR = 2.26, 95%CI = 1.48-3.45; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.20, 95%CI = 1.03-1.39). Further stratified analyses were conducted by ethnicity and sample size and produced similar results. No evidence of publication bias was found. This meta-analysis confirms that the AGT G-217A gene polymorphism is associated with essential hypertension susceptibility.
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Authors | R Yao, Y Y Du, Y Z Zhang, Q H Chen, L S Zhao, L Li |
Journal | Genetics and molecular research : GMR
(Genet Mol Res)
Vol. 14
Issue 2
Pg. 5527-34
(May 25 2015)
ISSN: 1676-5680 [Electronic] Brazil |
PMID | 26125750
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- AGT protein, human
- Angiotensinogen
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Topics |
- Angiotensinogen
(genetics)
- Essential Hypertension
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Hypertension
(genetics, pathology)
- Polymorphism, Single Nucleotide
- Risk Factors
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