Abstract | PURPOSE: METHODS: From November 2006 to June 2011, a total of 239 LNs from 201 patients who underwent bilateral thyroidectomy and radioactive iodine ablation therapy were included. The interactions between FNA-Tgs and serum TgAbs, and diagnostic performances between FNA with additional FNA-Tg and FNA alone according to the presence of serum TgAbs were evaluated using the generalized linear mixed model and the bootstrap method. RESULTS: From 106 (44.4%) malignant and 133 (55.6%) benign LNs, there were 32 (13.4%) LNs with detectable serum TgAb levels and 207 (86.6%) LNs with undetectable serum TgAb levels. In logistic regression analysis, a significant negative interaction was observed between FNA-Tgs and serum TgAbs (p = 0.031). In the absence of serum TgAbs, the diagnostic performances were superior in the FNA with FNA-Tg than in the FNA only. However, in the presence of serum TgAbs, the diagnostic performances of the FNA with FNA-Tg were not significantly different from the FNA only, even with a different cutoff value of FNA-Tg. CONCLUSIONS: Serum TgAbs may interfere with FNA-Tg studies and caution is advised while analyzing FNA-Tg for detection of LNM in patients with PTC.
|
Authors | Hyun Joo Shin, Hye Sun Lee, Eun-Kyung Kim, Hee Jung Moon, Ji Hye Lee, Jin Young Kwak |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 6
Pg. e0131096
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26121598
(Publication Type: Journal Article)
|
Chemical References |
- Autoantibodies
- anti-thyroglobulin
- Thyroglobulin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(blood)
- Biopsy, Fine-Needle
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(diagnosis, pathology)
- Male
- Middle Aged
- Postoperative Period
- Thyroglobulin
(blood)
- Young Adult
|