Abstract | OBJECTIVE: METHODS: We conducted a multicenter retrospective study of patients with surgical stage IIIC endometrial cancer from 1990 to 2011. Adjuvant RT alone was performed in 85 patients (40.3%) and adjuvant CTRT in 126 patients (59.7%). Disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method and Cox proportional hazards model. RESULTS: Stage IIIC1 and stage IIIC2 accounted for 63% and 37%, respectively. FIGO IIIC2 had a higher recurrence rate than FIGO IIIC1 (38.5% vs. 29.3%, p=0.172). Five-year OS and DFS were lower in FIGO IIIC2 than FIGO IIIC1 (85.1% vs. 76.9%, p=0.417; 71.0% vs. 59.2%, p=0.108, respectively). Eighteen patients (13.5%) in stage IIIC1 developed PALN recurrence, whereas only one (3.3%) in stage IIIC2 had PALN recurrence (p=0.001). In multivariate analysis, predictors of DFS were parametrial invasion (HR, 3.49; 95% CI, 1.83-6.64; p<0.001), higher grade (HR, 2.78; 95% CI, 1.31-5.89; p=0.008), and >3 positive pelvic nodes (HR, 1.84; 95% CI, 1.11-3.05; p=0.019). Combined CTRT did not affect DFS or OS in IIIC1 and IIIC2 compared with RT alone. CONCLUSION: CTRT showed comparable survival outcome to RT alone. Half of relapses (46%) in stage IIIC1 occurred in PALN region, whereas relapse in stage IIIC2 primarily occurred in distant metastasis (90%). Future randomized studies are needed to determine which subgroup may be most likely to benefit from CCRT.
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Authors | Mee Sun Yoon, Won Park, Seung Jae Huh, Hak Jae Kim, Young Seok Kim, Yong Bae Kim, Joo-Young Kim, Jong-Hoon Lee, Hun Jung Kim, Jihye Cha, Jin Hee Kim, Juree Kim, Won Sup Yoon, Jin Hwa Choi, Mison Chun, Youngmin Choi, Sei Kyung Chang, Kang Kyoo Lee, Myungsoo Kim |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 138
Issue 3
Pg. 519-25
(Sep 2015)
ISSN: 1095-6859 [Electronic] United States |
PMID | 26115977
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Adenocarcinoma
(drug therapy, pathology, radiotherapy, surgery)
- Adult
- Aged
- Aged, 80 and over
- Chemoradiotherapy, Adjuvant
- Disease-Free Survival
- Endometrial Neoplasms
(drug therapy, pathology, radiotherapy, surgery)
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- Radiotherapy, Adjuvant
- Retrospective Studies
- Young Adult
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