Random urine albumin:creatinine ratio in high-risk pregnancy - Is it clinically useful?

Abstract

We evaluated the frequency of measurable albuminuria (⩾6.00mg/L) for albumin:creatinine ratios (ACr) among 160 consecutive women attending high-risk clinics. Of last urine samples before delivery, 76 had measurable albuminuria and 41/76 (53.9%) had ACr ⩾2mg/mmol of which 7.3% had normal pregnancy outcome. 84 samples had albuminuria <6.00mg/L and 43/84 (51.2%) had ACr ⩾2mg/mmol of which 25.6% had normal pregnancy outcome (p=0.025). Excluding 48/160 (30.0%) dilute samples (urinary creatinine <3mM), no samples with unmeasurable albuminuria had ACr ⩾2mg/mmol. In pregnancy, urine is often dilute and without measurable albuminuria, leading to a clinically relevant proportion of false positive results by ACr.

• Authors: Dane A De Silva, Anne C Halstead, Anne-Marie Côté, Yasser Sabr, Peter von Dadelszen, Laura A Magee
• Journal: Pregnancy hypertension (Pregnancy Hypertens) Vol. 3 Issue 2 Pg. 112-4 (Apr 2013) ISSN: 2210-7789 [Print] Netherlands
• PMID: 26105946 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.