[Agranulocytosis related to fluindione: A case report].

Abstract

INTRODUCTION:

While in most countries warfarin is the preferred anti-vitamin K, fluindione, a molecule with a prolonged half-life remains largely prescribed in France. Some of its side effects, including immuno-allergic complications, remain poorly understood.

CASE REPORT:

A 77-year-old woman presented with a febrile severe neutropenia of immunoallergic mechanism with a favourable outcome associated with fluindione, introduced 25 days earlier for the treatment of atrial fibrillation.

CONCLUSION:

This rare side effect is a reminder of the importance of biological monitoring in the first weeks following the introduction of fluindione and key diagnostic elements and therapeutic aspects of iatrogenic agranulocytosis.

• Authors: S Ngo, Y Benhamou, G Armengol, G Sauvêtre, N Cailleux-Talbot, N Massy, G Buchonnet, H Lévesque
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 37 Issue 1 Pg. 58-61 (Jan 2016) ISSN: 1768-3122 [Electronic] France
• Vernacular Title: Agranulocytose à la fluindione: à propos d'un cas.
• PMID: 26096756 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Chemical References

• Anticoagulants
• Phenindione
• fluindione

Topics

• Aged
• Agranulocytosis (chemically induced, pathology)
• Anticoagulants (adverse effects)
• Chemotherapy-Induced Febrile Neutropenia (pathology)
• Drug Hypersensitivity (pathology)
• Female
• France
• Humans
• Phenindione (adverse effects, analogs & derivatives)