High mobility group A1 expression shows negative correlation with recurrence time in patients with glioblastoma multiforme.

Abstract

The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM. Paired initial and recurrent GBM specimens from the same patient were evaluated using immunohistochemical analysis. The association between HMGA1 expression and progression-free survival time (PFST) was analyzed. Three patients were confirmed with IDH-1 R132H mutations in both initial and recurrent groups (3/25, 12%). There was a significant difference in HMGA1 expression between initial and recurrent GBM (P=0.002), and patients with tumors expressing HMGA1 at higher level had a significantly shorter PFST (7.3 months versus 11.1months; P=0.044). Our study indicates that recurrent GBM express HMGA1 at a higher level and that HMGA1 overexpressoin is associated with shorter PFST in patients with GBM. These findings suggest that HMGA1 potentially plays an important role in the treatment of GBM.

• Authors: Bin Liu, Bo Pang, Huajie Liu, Yoshiki Arakawa, Rui Zhang, Bin Feng, Peng Zhong, Daiki Murata, Haitao Fan, Tao Xin, Guangyu Zhao, Wei Liu, Hua Guo, Liming Luan, Shangchen Xu, Susumu Miyamoto, Qi Pang
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 211 Issue 8 Pg. 596-600 (Aug 2015) ISSN: 1618-0631 [Electronic] Germany
• PMID: 26092597 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier GmbH. All rights reserved.

Chemical References

• HMGA Proteins
• Isocitrate Dehydrogenase

Topics

• Adult
• Brain Neoplasms (genetics, metabolism, mortality, pathology)
• Disease Progression
• Disease-Free Survival
• Female
• Glioblastoma (genetics, metabolism, mortality)
• HMGA Proteins (genetics, metabolism)
• Humans
• Isocitrate Dehydrogenase (genetics, metabolism)
• Male
• Middle Aged
• Mutation (genetics)
• Neoplasm Recurrence, Local (genetics, pathology)