Abstract | OBJECTIVE: DESIGN: Prospective study. SETTING: University hospital. PATIENT(S): INTERVENTION(S): Samples from adenomyotic nodules and homologous endometria were collected. Endometrial tissue was also obtained from a control group. MAIN OUTCOME MEASURE(S): RESULT(S):
Myostatin mRNA levels in adenomyotic nodule were higher than in eutopic endometrium and myostatin, activin A, and follistatin concentrations were higher than in control endometrium. No difference was observed for inhibin-α, activin B, and cripto mRNA levels. Increased mRNA levels of ActRIIa and ActRIIb were observed in adenomyotic nodules compared with eutopic endometrium and control endometrium. Immunofluorescent staining for myostatin and follistatin confirmed higher protein expression in both glands and stroma of patients with adenomyosis than in controls. CONCLUSION(S):
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Authors | Patrizia Carrarelli, Chih-Fen Yen, Felice Arcuri, Lucia Funghi, Claudia Tosti, Tzu-Hao Wang, Joseph S Huang, Felice Petraglia |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 104
Issue 3
Pg. 744-52.e1
(Sep 2015)
ISSN: 1556-5653 [Electronic] United States |
PMID | 26086422
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- FST protein, human
- Follistatin
- MSTN protein, human
- Myostatin
- RNA, Messenger
- activin A
- Activins
- ACVR2B protein, human
- Activin Receptors, Type II
- activin receptor type II-A
|
Topics |
- Activin Receptors, Type II
(analysis, genetics)
- Activins
(analysis)
- Adenomyosis
(genetics, metabolism, surgery)
- Adult
- Case-Control Studies
- Endometrium
(chemistry, surgery)
- Female
- Follistatin
(analysis, genetics)
- Humans
- Immunohistochemistry
- Myostatin
(analysis, genetics)
- Prospective Studies
- RNA, Messenger
(genetics)
- Real-Time Polymerase Chain Reaction
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