[Clinical observations of lenalidomide combination chemotherapy for relapsing or refractory multiple myeloma].

Abstract

OBJECTIVE:

To explore the clinical efficacies and toxicities of lenalidomide combination chemotherapy in the treatment of relapsing or refractory multiple myeloma (MM) patients.

METHODS:

A total of 14 MM patients were recruited to receive lenalidomide combination chemotherapy in Beijing Chaoyang hospital from June 2013 to October 2014. Lenalidomide 25 mg was taken orally daily or every alternate day for 21 days and resting for 7 days. The regimens were RD (lenalidomide and dexamethasone, n = 6), RCD (lenalidomide, ifosfamide and dexamethasone, n = 4), RDD (lenalidomide, liposomal doxorubicinand dexamethasone, n = 1), PRD (lenalidomide, velcade and dexamethasone, n = 1) and R+DECP (lenalidomide, cisplatin, etoposide, ifosfamide and dexamethasone, n = 2).

RESULTS:

Among them, two patients died during the first cycle of lenalidomide. Ten patients finished 2 cycles of treatment and 2 patients attained near complete remission or complete remission (nCR/CR), 6 partial remission (PR) and 2 stable disease (SD) with an overall response rate (ORR) of 8/10. Ten patients finished 3 cycles of treatment and 3 attained CR, 5 PR and 2 SD. Nine patients finished 4 cycles of treatment and 3 attained CR, 5 PR and 1 progressive disease (PD). Six patients finished 5 cycles of treatment and 1 attained CR, 3 PR and 2 PD. Three patients finished 6 cycles of treatment and 1 attained CR, 1 PR and 1 PD. And the most common adverse reactions were fatigue, loss of appetite and hypocytosis. Six patients died.

CONCLUSION:

The lenalidomide combination chemotherapy is both efficacious and safe in the treatment of relapsing or refractory MM.

• Authors: Xin Li, Wanjun Sun, Na An, Zhongxia Huang, Shilun Chen, Man Shen, Yuping Zhong, Jiajia Zhang, Ying Hu, Xiaokai Zhan
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 10 Pg. 745-8 (Mar 17 2015) ISSN: 0376-2491 [Print] China
• PMID: 26080845 (Publication Type: Journal Article)

Chemical References

• Thalidomide
• Lenalidomide

Topics

• Antineoplastic Combined Chemotherapy Protocols
• Beijing
• Humans
• Lenalidomide
• Multiple Myeloma
• Neoplasm Recurrence, Local
• Remission Induction
• Thalidomide (analogs & derivatives)