Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Abstract	Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
Authors	Michael Hawkes, Andrea L Conroy, Robert O Opoka, Sophie Namasopo, Kathleen Zhong, W Conrad Liles, Chandy C John, Kevin C Kain
Journal	Emerging infectious diseases (Emerg Infect Dis) Vol. 21 Issue 7 Pg. 1237-9 (Jul 2015) ISSN: 1080-6059 [Electronic] United States
PMID	26079933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antimalarials Artemisinins artemisinin
Topics	Antimalarials (pharmacology, therapeutic use) Artemisinins (pharmacology, therapeutic use) Child Child, Preschool Drug Resistance Female Genes, Protozoan Humans Infant Malaria, Falciparum (drug therapy, parasitology, pathology) Male Plasmodium falciparum (drug effects, genetics) Polymorphism, Single Nucleotide Sequence Analysis, DNA Uganda

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