Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood.

Abstract

OBJECTIVE:

Statins are currently the preferred pharmacological therapy in children with familial hypercholesterolemia (FH) with the aim to prevent premature cardiovascular disease (CVD). However, concerns have been raised that lowering cholesterol levels with statins could interfere with hormone production. In this study hormone concentrations were assessed in young adult FH subjects before and 10 years after the initiation of statins, and compared with their unaffected siblings.

METHODS:

All 214 FH children (8-18 years) who were previously randomized into a placebo-controlled trial evaluating the 2-year efficacy and safety of pravastatin, and their 95 unaffected siblings, were eligible. Women using oral contraceptives were excluded. Fasted blood samples were taken to measure lipids and testosterone (males), estradiol (females), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and dehydroepiandosterone (DHEAS).

RESULTS:

After ten years, gonadal steroid and gonadotropin concentrations were within the reference interval and did not differ between FH subjects (n = 88) and unaffected siblings (n = 62). Mean DHEAS concentrations (±standard deviation) in the FH subjects and female siblings were normally distributed within the reference interval, whereas male siblings had a higher mean DHEAS concentration than their FH brothers (12.9 [± 4.9] vs. 8.4 [± 3.0] μmol/L, respectively, p < 0.0001).

CONCLUSION:

After ten years of statin treatment, testosterone, estradiol, LH and FSH concentrations in young adult FH patients are within the reference interval and comparable to their unaffected siblings. These results strengthen current guidelines that statins in FH subjects could be safely used from childhood onwards to prevent premature CVD.

• Authors: Marjet J A M Braamskamp, D Meeike Kusters, Albert Wiegman, Hans J Avis, Frits A Wijburg, John J P Kastelein, A S Paul van Trotsenburg, Barbara A Hutten
• Journal: Atherosclerosis (Atherosclerosis) Vol. 241 Issue 2 Pg. 427-32 (Aug 2015) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 26079405 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• Follicle Stimulating Hormone, Human
• Gonadal Steroid Hormones
• Gonadotropins, Pituitary
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Lipids
• Testosterone
• Dehydroepiandrosterone
• Estradiol
• Luteinizing Hormone
• Pravastatin

Topics

• Adolescent
• Adult
• Age Factors
• Biomarkers (blood)
• Child
• Dehydroepiandrosterone (blood)
• Double-Blind Method
• Estradiol (blood)
• Female
• Follicle Stimulating Hormone, Human (blood)
• Gonadal Steroid Hormones (blood)
• Gonadotropins, Pituitary (blood)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use)
• Hyperlipoproteinemia Type II (blood, diagnosis, drug therapy, genetics)
• Lipids (blood)
• Luteinizing Hormone (blood)
• Male
• Netherlands
• Pravastatin (adverse effects, therapeutic use)
• Risk Assessment
• Risk Factors
• Sex Factors
• Testosterone (blood)
• Time Factors
• Treatment Outcome
• Young Adult