Abstract | BACKGROUND AND PURPOSE: METHODS: Fourteen patients with possible CBS and upper limb apraxia were enrolled. Each patient underwent two sessions of anodal tDCS (left and right PARC) and one session of placebo tDCS. Ideomotor upper limb apraxia was assessed using the De Renzi ideomotor apraxia test that is performed only on imitation. RESULTS: A significant improvement of the De Renzi ideomotor apraxia test scores (post-stimulation versus pre-stimulation) after active anodal stimulation over the left PARC was observed (χ(2) = 17.6, P = 0.0005), whilst no significant effect was noticed after active anodal stimulation over the right PARC (χ(2) = 7.2, P = 0.07). A post hoc analysis revealed a selective improvement in the De Renzi ideomotor apraxia score after active anodal stimulation over the left PARC compared with placebo stimulation considering both right (P = 0.03) and left upper limbs (P = 0.01). CONCLUSIONS: These findings indicate that tDCS to the PARC improves the performance of an ideomotor apraxia test in CBS patients and might represent a promising tool for future rehabilitation approaches.
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Authors | M Bianchi, M Cosseddu, M Cotelli, R Manenti, M Brambilla, M C Rizzetti, A Padovani, B Borroni |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 22
Issue 9
Pg. 1317-22
(Sep 2015)
ISSN: 1468-1331 [Electronic] England |
PMID | 26073740
(Publication Type: Journal Article)
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Copyright | © 2015 EAN. |
Topics |
- Aged
- Apraxia, Ideomotor
(etiology, therapy)
- Arm
(physiopathology)
- Basal Ganglia Diseases
(complications, rehabilitation)
- Female
- Gestures
- Humans
- Male
- Middle Aged
- Neurodegenerative Diseases
(complications, rehabilitation)
- Parietal Lobe
(physiopathology)
- Syndrome
- Transcranial Direct Current Stimulation
(methods)
- Treatment Outcome
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