Are there any causes for increased thyroid volume in women with prolactinoma?

Abstract

PURPOSE:

The aim of this study was to evaluate thyroid volume in women with prolactinoma and investigate the relationship between anabolic hormones [insulin, insulin like growth factor (IGF-1), estrogen] and thyroid volume in the patients.

MATERIAL-METHOD:

Sixty-three euthyroid women with prolactinoma and 60 healthy euthyroid women were included. Serum prolactin (PRL), thyroid-stimulating hormone (TSH), thyroxine (free T4), free tri-iodothyronine (free T3), insulin resistance (IR) which was estimated by the homeostasis model assessment, thyroidal microsome (anti-TPO), antithyroglobulin antibodies (TgAb), estradiol (E2), and insulin like growth factor (IGF-1) were evaluated, and thyroid volume was calculated by B-mode doppler USG.

RESULTS:

The mean thyroid volume was significantly higher in women with prolactinoma (82.5±15.1mL) than in healthy women (76±15.1mL)(P=0.014), but no correlation was found between thyroid volume and serum PRL levels (P=0.967). There were also no differences between thyroid volume, anabolic hormones (E2, IGF-1), and insulin resistance in women with prolactinoma (P=0.776, P=0.786, P=0.647, respectively).

CONCLUSIONS:

Our study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma.

• Authors: Berçem Ayçiçek Doğan, Tuğba Taşcı, Ayşe Arduç, Mazhar Müslüm Tuna, Dilek Berker, Serdar Güler
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 76 Issue 5 Pg. 595-600 (Oct 2015) ISSN: 2213-3941 [Electronic] France
• PMID: 26067294 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Autoantibodies
• anti-thyroglobulin
• Triiodothyronine
• Estradiol
• Insulin-Like Growth Factor I
• Prolactin
• Thyrotropin
• Thyroxine

Topics

• Adult
• Autoantibodies (blood)
• Estradiol (blood)
• Female
• Humans
• Insulin Resistance
• Insulin-Like Growth Factor I (analysis)
• Middle Aged
• Pituitary Neoplasms (blood, pathology)
• Prolactin (blood)
• Prolactinoma (blood, pathology)
• Retrospective Studies
• Thyroid Gland (diagnostic imaging, pathology)
• Thyrotropin (blood)
• Thyroxine (blood)
• Triiodothyronine (blood)
• Ultrasonography