We reported a case of metanephric
adenofibroma in a 10-year-old boy to describe the clinical, radiologic, and pathologic features and discuss its treatment and differential diagnosis.
Nephrectomy was performed for the patient; final histopathologic evaluation was that of a metanephric
adenofibroma. Epithelial and stromal elements were both positive for WT-1,
Vimentin, PAX2, and the epithelial
tumor cells were also positive for S100, AE1/AE3, PAX8, CK8/18, EMA and a few cells were positive for CK7. Larger vessel wall components were positive for SMA, Des,
caldesmon while capillary components were positive for CD10, CD31, and CD34. CA-9, α-
inhibin and CD-56 were negative in the
neoplasm. The Ki-67 labeling index was <1%. Metanephric
adenofibroma is a rare benign renal
tumor; the diagnosis of it relies on pathology and immunohistochemistry. As its rarity, there is no standard treatment for this disease. The majority of patients underwent
nephrectomy and had good prognosis, as it is a
benign neoplasm.