Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules.

Abstract

Vascular endothelial contributes to the metabolism and interconversion of extracellular adenine nucleotides via ecto-ATPase/ADPase (CD39) and ecto-5'nucleotidase (CD73) activities. These enzymes collectively dephosphorylate ATP, ADP, and AMP with the production of additional adenosine. In the vascular system, adenine nucleotides (ATP and ADP) and nucleoside adenosine represent an important class of extracellular molecules involved in modulating the processes linked to vascular thrombosis exerting various effects in platelets. Yet, the mechanisms by which the extracellular ATP metabolism in the local environment trigger pro-thrombotic and anti-thrombotic states are yet to be fully elucidated. In this article, the relative contribution of extracellular ATP metabolism in platelet regulation is explored.

• Authors: Eduardo Fuentes, Iván Palomo
• Journal: Vascular pharmacology (Vascul Pharmacol) Vol. 75 Pg. 1-6 (Dec 2015) ISSN: 1879-3649 [Electronic] United States
• PMID: 25989108 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Antigens, CD
• Adenosine Triphosphate
• 5'-Nucleotidase
• Apyrase
• CD39 antigen
• Adenosine

Topics

• 5'-Nucleotidase (metabolism)
• Adenosine (metabolism)
• Adenosine Triphosphate (metabolism)
• Animals
• Antigens, CD (metabolism)
• Apyrase (metabolism)
• Blood Platelets (metabolism)
• Endothelial Cells (metabolism)
• Endothelium, Vascular (metabolism)
• Humans
• Platelet Activation (physiology)
• Thrombosis (metabolism)