Abstract | UNLABELLED: MATERIALS AND METHODS: The study included adolescents aged 13.4 ± 0.42 yr divided into 2 groups depending on anti-Helicobacter therapy ( AHBT). We measured levels of direct and indirect bilirubins, their ratio, and direct bilirubin content as percentage of total bilirubin at admission to and discharge from the hospital. The daily incremental growth of both bilirubin fractions was calculated RESULTS: Detailed analysis revealed negative effect of AHBT on the GTF system attributable to its impaired stability in patients with abnormal genotype. CONCLUSION: Prescription of AHBT to children with Gilbert's syndrome requires the thorough choice of medications and monitoring of their potential effect on the GFT system.
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Authors | O K Botvin'ev, A I Kolotilina, I E Turina, G M Dubrovina |
Journal | Klinicheskaia meditsina
(Klin Med (Mosk))
Vol. 92
Issue 12
Pg. 55-8
( 2014)
ISSN: 0023-2149 [Print] Russia (Federation) |
PMID | 25980300
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Glucuronosyltransferase
- Bilirubin
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Topics |
- Adolescent
- Anti-Bacterial Agents
(adverse effects)
- Bilirubin
(blood)
- Gilbert Disease
(blood, enzymology)
- Glucuronosyltransferase
(drug effects)
- Helicobacter
(drug effects)
- Humans
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