Abstract |
Recent studies suggest that homeostasis of lipid metabolism is crucial for the function of various immune cells. Oxygenated derivatives of cholesterol ( oxysterols) are well-known regulators of lipid metabolism and have diverse functions, such as inhibition of cholesterol synthesis, efflux of intracellular cholesterol, synthesis of cholesterol esters, and activation of liver X receptors (LXRs). In this review, we introduce novel roles of the oxysterol receptors LXRs in the immune system, including regulation of inflammatory responses, T cell expansion, immunoglobulin production, and antitumor responses. We also discuss lipid-mediated signaling as a potential target for treatment of immune diseases.
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Authors | Satoshi Nunomura, Makoto Makishima, Chisei Ra |
Journal | Biomolecular concepts
(Biomol Concepts)
Vol. 1
Issue 5-6
Pg. 381-7
(Dec 01 2010)
ISSN: 1868-5021 [Print] Germany |
PMID | 25962011
(Publication Type: Journal Article)
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