Recovery of Cognitive Dysfunction via Orally Administered Redox-Polymer Nanotherapeutics in SAMP8 Mice.

Abstract

Excessively generated reactive oxygen species are associated with age-related neurodegenerative diseases. We investigated whether scavenging of reactive oxygen species in the brain by orally administered redox nanoparticles, prepared by self-assembly of redox polymers possessing antioxidant nitroxide radicals, facilitates the recovery of cognition in 17-week-old senescence-accelerated prone (SAMP8) mice. The redox polymer was delivered to the brain after oral administration of redox nanoparticles via a disintegration of the nanoparticles in the stomach and absorption of the redox polymer at small intestine to the blood. After treatment for one month, levels of oxidative stress in the brain of SAMP8 mice were remarkably reduced by treatment with redox nanoparticles, compared to that observed with low-molecular-weight nitroxide radicals, resulting in the amelioration of cognitive impairment with increased numbers of surviving neurons. Additionally, treatment by redox nanoparticles did not show any detectable toxicity. These findings indicate the potential of redox polymer nanotherapeutics for treatment of the neurodegenerative diseases.

• Authors: Pennapa Chonpathompikunlert, Toru Yoshitomi, Long Binh Vong, Natsuka Imaizumi, Yuki Ozaki, Yukio Nagasaki
• Journal: PloS one (PLoS One) Vol. 10 Issue 5 Pg. e0126013 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25955022 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Polymers
• Reactive Oxygen Species

Topics

• Administration, Oral
• Aging (drug effects)
• Animals
• Antioxidants (administration & dosage)
• Cognition Disorders (drug therapy, metabolism, pathology)
• Mice
• Nanoparticles (administration & dosage)
• Oxidation-Reduction
• Oxidative Stress (drug effects)
• Polymers (administration & dosage)
• Reactive Oxygen Species