Abstract | BACKGROUND:
Surfactant proteins B and C are mainly synthesized, secreted by alveolar type II cells, and affected by hypoxia and mechanical stretches. We hypothesized that their serum levels might be altered by intermittent hypoxia and swing of intrathoracic pressure of obstructive sleep apnea (OSA). METHODS: Consecutive 140 middle-aged males, suspicious of OSA determined by polysomnography, were studied. Surfactant proteins B and C were determined by ELISA. RESULTS:
Surfactant protein B (41.39 ± 6.01 vs 44.73 ± 7.62 ng/L, p = 0.005), not C (32.60 ± 6.00 vs 32.43 ± 6.44 ng/L, p = 0.61), significantly lowered in moderate to severe OSA subjects than in non to mild OSA subjects. Severity of OSA is inversely correlated with serum surfactant protein B. Adjusting age, body mass index, and smoking history, compared to subjects with surfactant protein B (SP-B) ≥43.35 ng/L, those with SP-B <43.35 ng/L showed significantly increased 1.528-fold risk for moderate to severe OSA (p = 0.009), whereas no association between surfactant protein C and OSA was observed. Prevalence of moderate to severe OSA in lower SP-B group is higher than that in higher SP-B group (62.7 vs 38.4 %, p = 0.003). Serial and parallel tests on Epworth sleep scale (ESS) and SP-B evaluation can be complementary and prove helpful with high specificity (94.44 %) and sensitivity (84.48 %) to detect moderate to severe OSA. CONCLUSIONS:
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Authors | Liang Shao, Nanfang Li, Xiaoguang Yao, Mulalibieke Heizati, Arikin Abdireim, Yingchun Wang, Zufeiya Abulikemu, Delian Zhang, Guijuan Chang, Ling Zhou, Jing Hong, Yongping Zhang, Jianqiong Kong, Xiangyang Zhang |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 20
Issue 1
Pg. 25-31
(Mar 2016)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 25953386
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Pulmonary Surfactant-Associated Protein B
- Pulmonary Surfactant-Associated Protein C
- SFTPC protein, human
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Hypoxia
(blood, diagnosis)
- Male
- Middle Aged
- Pulmonary Alveoli
(physiopathology)
- Pulmonary Surfactant-Associated Protein B
(blood)
- Pulmonary Surfactant-Associated Protein C
(blood)
- Reference Values
- Sleep Apnea, Obstructive
(blood, diagnosis)
- Statistics as Topic
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