Strong expression of paired-like homeodomain transcription factor 1 (PITX1) is associated with a favorable outcome in human osteosarcoma.

Abstract

Paired-like homeodomain transcription factor 1 (PITX1) has been implicated as a tumor suppressor in various cancers. However, the biological and clinical significance of PITX1 in osteosarcoma has not been fully elucidated. Here, we studied the expression and clinical significance of PITX1 in 6 normal lower limb bone tissue specimens and 35 osteosarcoma tissue samples by immunohistochemistry. PITX1 was expressed in all normal tissues (6/6, 100 %) and in 85.7 % (30/35) of tumor tissues (P > 0.05). In addition, all normal tissue specimens showed high PITX1 expression (6/6, 100 %) while only 23.3 % (7/30) osteosarcoma tissue specimens had high PITX1 expression (P < 0.05). Patients with median overall survival (OS) >12 months had significantly higher PITX1 levels compared with those whose median OS was less than or equal to 12 months (P < 0.05 or 0.001). Furthermore, patients with lung metastasis had significantly lower PITX1 levels than patients without lung metastasis. In conclusion, PITX1 expression is downregulated in osteosarcoma and correlates with patient survival and lung metastasis.

• Authors: Gengbin Kong, Zhaoyong Liu, Kezhou Wu, Ying Zhang, Zhihua Deng, Weili Feng, Shubiao Chen, Hu Wang
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 10 Pg. 7735-41 (Sep 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25936343 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Paired Box Transcription Factors
• homeobox protein PITX1

Topics

• Adolescent
• Adult
• Biomarkers, Tumor (metabolism)
• Bone Neoplasms (metabolism, mortality, pathology)
• Child
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Lung Neoplasms (metabolism, mortality, secondary)
• Male
• Middle Aged
• Neoplasm Staging
• Osteosarcoma (metabolism, mortality, pathology)
• Paired Box Transcription Factors (metabolism)
• Prognosis
• Survival Rate
• Young Adult