The clinicopathological characteristics and rational treatment of primary laryngeal mucosa-associated lymphoid tissue (
MALT) lymphoma are still unclear and need to be further defined due to the paucity of this separate
lymphoma.Herein, a supraglottic primary
MALT lymphoma was described with detailed
clinical course, intervention, and follow-up. To date, research of laryngeal
MALT lymphoma has seldom been initiated. Our experience in this case will help to expand our understanding of this unique disease. A 58-year-old female presented with a history of progressive
hoarseness for about 10 months. Multiple laryngoscopy examinations revealed severe
hypertrophy of left ventricular band. She was admitted to our department with residual
MALT lymphoma of supraglottic region after partial resection by
laser. After systemic evaluation, she was staged as IEA, International Prognostic Index score 0. Irradiation of
intensity modulated radiotherapy technique with a dose of 30.6 Gy/17f to the
tumor and 25.5 Gy/17f to the related lymphatic drainage area achieved a complete remission. The disease-free survival has reached to 4 years. The irradiation related acute and late side effects were mild.Radiotherapy is the first option for limited-stage primary laryngeal
MALT lymphoma because of excellent treatment outcome.