How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

Abstract

Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.

• Authors: Pierre Besson, Virginie Driffort, Émeline Bon, Frédéric Gradek, Stéphan Chevalier, Sébastien Roger
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1848 Issue 10 Pt B Pg. 2493-501 (Oct 2015) ISSN: 0006-3002 [Print] Netherlands
• PMID: 25922224 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• A Kinase Anchor Proteins
• Adaptor Proteins, Signal Transducing
• GPI-Linked Proteins
• Voltage-Gated Sodium Channels
• Sodium

Topics

• A Kinase Anchor Proteins (genetics, metabolism)
• Adaptor Proteins, Signal Transducing (genetics, metabolism)
• Cell Movement
• GPI-Linked Proteins (genetics, metabolism)
• Gene Expression Regulation, Neoplastic
• Humans
• Membrane Potentials
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Neoplasms (genetics, metabolism, pathology)
• Signal Transduction
• Sodium (metabolism)
• Tumor Microenvironment
• Voltage-Gated Sodium Channels (genetics, metabolism)