Inherited deficiencies of the late-acting complement components other than C9 found among healthy blood donors.

Abstract

Among sera from 145,640 healthy blood donors in Osaka, 16 were found to have abnormalities in late-acting complement components other than C9. It was found that of these 16 sera, 2 were deficient in C5, 4 in C6, 6 in C7 and 4 in C8 alpha-gamma-subunit. The incidence of deficiency of each component among the Osaka blood donors was calculated as follows: C5 deficiency, 0.0014%; C6 deficiency, 0.0027%; C7 deficiency, 0.0041%; C8 alpha-gamma-subunit deficiency, 0.0027%. We confirmed that 13 donors were healthy and 12 had no past history related to a complement component deficiency. From these results, not only C9 deficiency but also deficiencies of the other late-acting complement components were found among the healthy blood donors, but no early-acting component deficiencies were noted.

• Authors: S Inai, Y Akagaki, T Moriyama, Y Fukumori, K Yoshimura, S Ohnoki, H Yamaguchi
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 90 Issue 3 Pg. 274-9 ( 1989) ISSN: 0020-5915 [Print] Switzerland
• PMID: 2592116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Complement C5
• Complement C6
• Complement C7
• Complement C8
• Complement C9
• Complement System Proteins

Topics

• Blood Donors
• Complement Activation
• Complement C5 (deficiency, genetics)
• Complement C6 (deficiency)
• Complement C7 (deficiency)
• Complement C8 (deficiency)
• Complement C9 (deficiency)
• Complement System Proteins (deficiency)
• Hemolysis
• Humans
• Japan
• Pedigree