Abstract |
Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significantly greater reduction in these parameters was found after treatment with HAP compared to placebo, indicating an improvement in lower limb venous circulation.
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Authors | C Schmidt, R Gavoille, P Perez, J Schmitt |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 37
Issue 1
Pg. 37-40
( 1989)
ISSN: 0031-6970 [Print] Germany |
PMID | 2591460
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Amino Alcohols
- Heptaminol
- Adenosine Monophosphate
- heptaminol AMP amidate
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Topics |
- Adenosine Monophosphate
(analogs & derivatives, therapeutic use)
- Amino Alcohols
(therapeutic use)
- Double-Blind Method
- Female
- Heptaminol
(analogs & derivatives, therapeutic use)
- Humans
- Leg
(blood supply)
- Male
- Middle Aged
- Plethysmography
- Regional Blood Flow
(drug effects)
- Time Factors
- Varicose Veins
(drug therapy, physiopathology)
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