Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period.

Abstract

OBJECTIVE:

Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies in the post-Chernobyl period.

MATERIALS AND METHODS:

We analyzed gene expression levels of NF-κB1, NF-κB2, and Rel in 49 B-cell chronic lymphocytic leukemia, 8 B-cell non-Hodgkin's lymphoma, 3 acute myeloid leukemia, 3 chronic myeloid leukemia, 2 hairy cell leukemia, 2 myelodysplastic syndrome, and 2 T-cell large granular lymphocytic leukemia patients using real-time polymerase chain reaction.

RESULTS:

Expression levels of NF-κB1, NF-κB2, and Rel genes were found to be deregulated.

CONCLUSION:

These results could be accepted as specific gene traces to radiation-induced leukemia or as potential candidates for new diagnostic biomarker studies. Larger experiments and non-exposed control malignant cell populations are needed to clarify these suggestions.

• Authors: Hakan Savlı, Ramis Ufuk Akkoyunlu, Naci Çine, Daniil F Gluzman, Michael P Zavelevich, Lilia M Sklyarenko, Stella V Koval, Deniz Sünnetçi
• Journal: Turkish journal of haematology : official journal of Turkish Society of Haematology (Turk J Haematol) Vol. 33 Issue 1 Pg. 8-14 (Mar 05 2016) ISSN: 1308-5263 [Electronic] Turkey
• PMID: 25912249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• NF-kappa B
• NF-kappa B p50 Subunit
• NF-kappa B p52 Subunit
• Transcription Factor RelA

Topics

• Adult
• Aged
• Chernobyl Nuclear Accident
• Female
• Genes, rel
• Humans
• Leukemia, Radiation-Induced (epidemiology, etiology, genetics)
• Lymphoma (epidemiology, etiology, genetics, metabolism)
• Male
• Middle Aged
• Myelodysplastic Syndromes (epidemiology, etiology, genetics, metabolism)
• NF-kappa B (biosynthesis, genetics)
• NF-kappa B p50 Subunit (biosynthesis, genetics)
• NF-kappa B p52 Subunit (biosynthesis, genetics)
• Neoplasms, Radiation-Induced (epidemiology, etiology, genetics, metabolism)
• Real-Time Polymerase Chain Reaction
• Transcription Factor RelA (biosynthesis, genetics)
• Ukraine (epidemiology)
• Young Adult