Abstract | BACKGROUND AND OBJECTIVE: MATERIAL AND METHODS: This pilot study involved 30 smokers with at least six teeth with a clinical attachment loss of ≥ 5 mm and probing pocket depth ( PPD) of ≥ 5 mm. They were randomly assigned into one of three groups (n = 10): (i) 3 g daily of placebo gel applied topically (using a dental tray with the gel overnight) + periodontal debridement; (ii) 3 g daily of a 15% Mtz benzoate gel applied topically (using a dental tray with the gel overnight) + periodontal debridement; and (iii) a daily single dose of 750 mg Mtz ( Flagyl(®)) + periodontal debridement. Clinical parameters (visible plaque index, gingival bleeding index [GBI], relative attachment level and PPD) and quantitative analysis (by real-time polymerase chain reaction) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia were assessed at baseline and at 1, 3 and 6 mo after periodontal debridement. RESULTS: There was no statistically significant difference in the average GBI and visible plaque index values at baseline between the groups (p ≥ 0.05). There was no significant difference between groups in all parameters evaluated (p ≥ 0.05). Significant reductions in GBI at 3 and 6 mo were observed in all groups (p < 0.05). Significant reductions in both PPD and relative attachment level at 1, 3 and 6 mo were observed in all groups (p < 0.05). Significant reductions in bacterial levels at 7 and 30 d were observed in all groups (p < 0.05). CONCLUSION:
|
Authors | C C Bergamaschi, M P Santamaria, L A Berto, K Cogo-Müller, R H L Motta, E A Salum, F H Nociti Júnior, J M Goodson, F C Groppo |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 51
Issue 1
Pg. 50-9
(Feb 2016)
ISSN: 1600-0765 [Electronic] United States |
PMID | 25900347
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
|
Topics |
- Chronic Periodontitis
(drug therapy)
- Dental Scaling
- Follow-Up Studies
- Humans
- Metronidazole
- Periodontal Attachment Loss
(drug therapy)
- Periodontal Debridement
- Periodontal Index
- Periodontal Pocket
(drug therapy)
- Pilot Projects
- Smoking
|