Autoimmune connective tissue diseases.

Abstract

Rheumatic diseases (RDs) occur preferentially in women, often during the childbearing age. The interaction of pregnancy and the RD is varied, ranging from spontaneous improvement to aggravation of disease symptoms or life-threatening flares. Risks for the mother with RD and the child differ in regard to the presence of organ manifestations, organ damage, disease activity, presence of specific autoantibodies, and therapy. Pregnancy complications comprise hypertension, preeclampsia, premature delivery, and side effects of therapy. Adverse pregnancy outcomes include recurrent miscarriage, intrauterine growth restriction, and fetal demise, and they are frequently encountered in RD with organ manifestations and harmful autoantibodies. Because of the difference in the prevalence of RDs, knowledge on the gestational course of disease and pregnancy outcome is limited to the fairly common RDs such as rheumatoid arthritis, systemic lupus erythematosus, and antiphospholipid syndrome. Pregnancies in RD are connected with increased risks for mother and child and need interdisciplinary care and management.

• Authors: Monika Østensen, Irene Cetin
• Journal: Best practice & research. Clinical obstetrics & gynaecology (Best Pract Res Clin Obstet Gynaecol) Vol. 29 Issue 5 Pg. 658-70 (Jul 2015) ISSN: 1532-1932 [Electronic] Netherlands
• PMID: 25891380 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Autoantibodies

Topics

• Abortion, Spontaneous (immunology)
• Autoantibodies (blood)
• Autoimmune Diseases (blood, complications, drug therapy)
• Family Planning Services
• Female
• Fetal Growth Retardation (immunology)
• Humans
• Pregnancy
• Pregnancy Complications (immunology, prevention & control, therapy)
• Pregnancy Outcome
• Premature Birth (immunology)
• Rheumatic Diseases (blood, complications, drug therapy)