Abstract | BACKGROUND: METHODS: The RNFL thickness was assessed using optical coherence tomography (OCT) in patients with MCI, AD (mild, moderate and severe) and the age matched controls. RESULTS: The thickness of RNFL in the superior quadrant and total mean values are gradually and significantly decreased from MCI to severe AD when compared to that in the controls. There is also a significant reduction of the retinal nerve fiber layer in the inferior quadrant in severe AD patients. CONCLUSIONS: Our data indicate that the retinal nerve fiber layer degeneration is paralleled with dementia progression. Owing to its non-invasive and cost effective nature, monitoring RNFL thickness may have a value in assessing disease progression and the efficacy of any treatments.
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Authors | Dachuan Liu, Lina Zhang, Zhen Li, Xuxiang Zhang, Yue Wu, Huiqing Yang, Baoquan Min, Xinqing Zhang, Daqing Ma, Yan Lu |
Journal | BMC neurology
(BMC Neurol)
Vol. 15
Pg. 14
(Feb 21 2015)
ISSN: 1471-2377 [Electronic] England |
PMID | 25886372
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Alzheimer Disease
(physiopathology)
- Case-Control Studies
- Cognitive Dysfunction
(physiopathology)
- Female
- Humans
- Male
- Middle Aged
- Nerve Fibers
(pathology)
- Retina
(pathology)
- Tomography, Optical Coherence
- Vision Disorders
(etiology)
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