Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan.

Abstract

BACKGROUND:

Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor). However, patients with GP may have a better prognosis than patients with NET G1. This fact emphasizes the importance of differentiating GP from NET G1, but few studies have reported the epidemiology and histopathology of GP because of its rarity. To differentiate GP from NET G1 with ease, we conducted a multi-institutional retrospective study analyzing the morphometric and immunohistochemical features of this tumor.

METHODS:

Since only a limited number of patients with GP could be identified in our institute, we conducted a multi-institutional retrospective study of GP in Japan, which was approved by the Ethics Committee of our medical institute. The obtained tissue sections underwent detailed morphometric and immunohistochemical analyses. Additionally, to differentiate GP from NET G1 with ease, immunohistochemical findings were compared.

RESULTS:

In our examination of 12 cases of duodenal GP, we found that epithelioid cells of GP exhibited positive reactivity for progesterone receptor and pancreatic polypeptide, whereas tumor cells of NET G1 were completely negative reactivity for both. Additionally, although GP is considered to be an extremely rare NET, we found that four (40.0%) of the ten patients at our institute with duodenal NET G1 actually had GP.

CONCLUSIONS:

Although GP is regarded as a rare NET, our results suggest that it accounts for a substantial percentage of duodenal NETs. Additionally, confirmation of immunoreactivity for progesterone receptor and pancreatic polypeptide can assist in differentiating GP from NET G1.

• Authors: Yoichiro Okubo, Tetsuo Nemoto, Megumi Wakayama, Naobumi Tochigi, Minoru Shinozaki, Takao Ishiwatari, Kyoko Aki, Masaru Tsuchiya, Hajime Aoyama, Kanade Katsura, Takeshi Fujii, Takashi Nishigami, Tomoyuki Yokose, Yasuo Ohkura, Kazutoshi Shibuya
• Journal: BMC cancer (BMC Cancer) Vol. 15 Pg. 269 (Apr 12 2015) ISSN: 1471-2407 [Electronic] England
• PMID: 25886293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Receptors, Progesterone
• Pancreatic Polypeptide

Topics

• Aged
• Biomarkers, Tumor (genetics)
• Carcinoid Tumor (diagnosis, genetics, pathology)
• Diagnosis, Differential
• Duodenum (pathology)
• Female
• Humans
• Male
• Middle Aged
• Neuroendocrine Tumors (diagnosis, genetics, pathology)
• Pancreatic Polypeptide (genetics)
• Paraganglioma (diagnosis, genetics, pathology)
• Receptors, Progesterone (genetics, metabolism)