Abstract | PURPOSE OF REVIEW: Primary aldosteronism is increasingly recognized as a common secondary cause of hypertension. Successful demonstration of a unilateral cause (e.g. a classical 'Conn's adenoma') offers the potential for curative adrenalectomy. Adrenal vein sampling (AVS), in conjunction with cross-sectional imaging, remains the 'gold standard' for distinguishing unilateral and bilateral disease, but is technically demanding and frequently unsuccessful or inconclusive. As such, alternative strategies for lateralization, including nuclear medicine techniques, are being developed and brought into clinical practice. RECENT FINDINGS: SUMMARY: Increasing experience with 11C-metomidate PET-CT supports its use as an adjunct to AVS when this has failed, is ambiguous, or cannot be undertaken.
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Authors | Andrew S Powlson, Mark Gurnell, Morris J Brown |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 22
Issue 3
Pg. 150-6
(Jun 2015)
ISSN: 1752-2978 [Electronic] England |
PMID | 25871964
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Etomidate
(analogs & derivatives)
- Humans
- Hyperaldosteronism
(diagnostic imaging)
- Positron-Emission Tomography
(methods)
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