[Comparative study of clinical features between unilateral and bilateral orbital IgG4-related disease].

Abstract

OBJECTIVE:

Descriptive and comparative study of patients with orbital IgG4-related disease.

MATERIAL AND METHODS:

A review and analysis of the cases diagnosed with inflammatory orbital lesion related to IgG4 by the Ophthalmic Pathology Service in the Dr. Luis Sánchez Bulnes Hospital.

RESULTS:

A total of 9 cases were found, in which 66% were women, and with a mean age of 48 years and time to diagnosis of 2 years. Unilateral involvement was observed in 56% of cases. All the females experienced pain, and there was an optimal response to corticosteroid treatment in 100% of patients who required medical treatment (one case showed spontaneous resolution). In bilateral cases (44%), only 25% were female, and none had pain as a presenting symptom. Furthermore, 25% of these patients required a combination with immunosuppressants to control inflammation.

CONCLUSIONS:

Clinical presentation of patients with unilateral orbital IgG4-related disease differs from those with bilateral involvement.

• Authors: I Coloma-González, A Ceriotto, J Flores-Preciado, S Corredor-Casas, G Salcedo-Casillas
• Journal: Archivos de la Sociedad Espanola de Oftalmologia (Arch Soc Esp Oftalmol) Vol. 90 Issue 9 Pg. 407-13 (Sep 2015) ISSN: 1989-7286 [Electronic] Spain
• Vernacular Title: Estudio comparativo de los hallazgos clínicos en la enfermedad orbitaria asociada a IgG4 con afectación unilateral vs. bilateral.
• PMID: 25865652 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2014 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulin G

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Chronic Disease
• Cross-Sectional Studies
• Dacryocystitis (diagnosis, drug therapy, etiology, immunology)
• Delayed Diagnosis
• Eye Pain (etiology)
• Female
• Humans
• Hypergammaglobulinemia (complications)
• Immunoglobulin G (analysis)
• Male
• Middle Aged
• Mikulicz' Disease (diagnosis, drug therapy, etiology, immunology)
• Orbital Diseases (diagnosis, drug therapy, etiology, immunology)