Efficacy of perampanel in refractory nonconvulsive status epilepticus and simple partial status epilepticus.

Abstract

We provide some evidence concerning the efficacy of perampanel (PER) in refractory status epilepticus (SE). We retroactively identified patients with SE treated in our department by searching for the term "status epilepticus" in the electronic archive of medical records. We present and analyze in this paper the subset of data of the patients treated with PER. We analyzed ten episodes of SE in nine patients. At the first administration, PER was given in a dosage of 6mg to most of our patients (7 of 10). On average, PER was administered as the 6th antiepileptic drug (AED) (range: 2-10). Depending on the criterion for efficacy, PER appears effective for the termination of SE in 2 to 6 (of 10) episodes. Unfortunately, safety data for the administration of PER with loading doses needed for the treatment of SE are lacking. Because of this, PER should be used very carefully in refractory SE and only after first-line treatment options have failed.

• Authors: Juliane Redecker, Matthias Wittstock, Reiner Benecke, Johannes Rösche
• Journal: Epilepsy & behavior : E&B (Epilepsy Behav) Vol. 45 Pg. 176-9 (Apr 2015) ISSN: 1525-5069 [Electronic] United States
• PMID: 25819947 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Anticonvulsants
• Nitriles
• Pyridones
• perampanel

Topics

• Aged
• Aged, 80 and over
• Anticonvulsants (therapeutic use)
• Electronic Health Records (trends)
• Female
• Humans
• Male
• Middle Aged
• Nitriles
• Pyridones (therapeutic use)
• Retrospective Studies
• Status Epilepticus (diagnosis, drug therapy)
• Treatment Outcome