Barnidipine real-life tolerability in arterial hypertension: results from the BASIC-HT study.

Abstract

INTRODUCTION:

Blood pressure (BP) is generally poorly controlled in hypertensive patients. One cause is poor adherence to drugs, which can be improved by treatments combining good efficacy and tolerability. Barnidipine is a strong lipophilic calcium channel blocker (CCB) with efficacy similar to other dihydropyridines.

OBJECTIVE:

BASIC HT is an observational study in a large population of patients with essential hypertension to evaluate the tolerability of barnidipine in a real-life setting.

METHODS:

20479 patients were enrolled in the study. Tolerability and efficacy was assessed at 2 visits during a 3-month period. 20275 patients were included in the analysis.

RESULTS:

Adverse events were reported by 10.6% of the patients, leading to treatment discontinuation in 3%. Events were those expected with CCBs. The drop-out rate was 8%. Mean systolic and diastolic pressure decreased from 159.6 to 138.2 and from 92.5 to 81.7 mmHg.

CONCLUSION:

The decrease in BP, is probably due to stimulation of good adherence by barnidipine.

• Authors: R Lins, P Marckx, R Vandebeek, C Vanhoutvinck, O Neuville
• Journal: Acta clinica Belgica (Acta Clin Belg) Vol. 70 Issue 4 Pg. 244-50 (Aug 2015) ISSN: 1784-3286 [Print] England
• PMID: 25816195 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• mepirodipine
• Nifedipine

Topics

• Adult
• Aged
• Aged, 80 and over
• Calcium Channel Blockers (adverse effects, therapeutic use)
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Medication Adherence
• Middle Aged
• Nifedipine (adverse effects, analogs & derivatives, therapeutic use)
• Young Adult