Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha: An Emerging Target for Neuroprotection in Parkinson's Disease.

Abstract

Mutations in mitochondrial genes, oxidative insults, imbalance in redox mechanisms and dysregulated mitophagy are some of the leading causes for mitochondrial dysfunction and subsequent neurodegeneration in Parkinson's disease. Targeting mitochondrial dysfunction and prolonging neuronal survival could potentially prove to be useful neuroprotective strategies. In some recent investigations, peroxisome proliferator activated receptor gamma coactivator 1 alpha mediated mitochondrial biogenesis and its ability to restore reactive oxygen species-detoxifying enzymes have been observed in preclinical studies. In this review, we discuss about physiological importance of peroxisome proliferator activated receptor gamma coactivator 1 alpha along with a list of its activators that could prove useful as possible neuroprotectants in Parkinson's disease.

• Authors: Nihar Ranjan Das, Shyam Sunder Sharma
• Journal: CNS & neurological disorders drug targets (CNS Neurol Disord Drug Targets) Vol. 14 Issue 8 Pg. 1024-30 ( 2015) ISSN: 1996-3181 [Electronic] United Arab Emirates
• PMID: 25808897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antiparkinson Agents
• Neuroprotective Agents
• PPARGC1A protein, human
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
• Ppargc1a protein, mouse
• Ppargc1a protein, rat
• Transcription Factors

Topics

• Animals
• Antiparkinson Agents (chemistry, pharmacology, therapeutic use)
• Humans
• Mitochondria (drug effects, metabolism)
• Neuroprotective Agents (chemistry, pharmacology, therapeutic use)
• Parkinson Disease (drug therapy, metabolism)
• Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
• Transcription Factors (metabolism)