Efficacy and safety of a lindane 1% treatment regimen for scabies, confirmed by dermoscopy-guided skin scraping with microscopic examination.

Abstract

BACKGROUND:

This is the first study investigating scabies treatment since 1992 to involve examination of patients with microscopically confirmed scabies.

AIM:

To assess the efficacy of 1% lindane cream in treating microscopically confirmed scabies, and to determine the utility of dermoscopy-guided skin scraping with microscopic examination (DSGSS-ME) in evaluating the efficacy of scabies treatment.

METHODS:

This retrospective study analysed patients treated for scabies between January 2012 and December 2013. From the hospital database, 287 cases of scabies were identified and 50 were enrolled in the study. Patients were treated with 1% lindane cream twice weekly (days 0 and 1) and were evaluated with DSGSS-ME on day 7. Treatment and evaluations were repeated once weekly until a negative DSGSS-ME result was obtained.

RESULTS:

The cumulative efficacy of lindane 1% cream was 40% (20/50) after 1 week, 88% (44/50) after 2 weeks and 98% (49/50) after 3 weeks of treatment. There was a statistically significant difference between the 1- and 2-week (P = 0.03), and 1- and 3-week (P = 0.02) treatments. A total of 90 post-treatment DSGSS-MEs were performed, with a sensitivity of 97.3% (95% CI 85.8-99.9) and a negative predictive value of 98.2% (95% CI 90.1-100). Specificity and positive predictive value were 100%, as this procedure cannot yield false-positive results, because it relies on finding mites, eggs or faeces.

CONCLUSIONS:

We suggest that a twice-weekly schedule (on consecutive days) of 1% lindane treatment lasting at least 2 weeks is required to clear scabies. DSGSS-ME appears to be a good method to evaluate the efficacy of scabies treatment. This study introduces a safe and effective method to treat scabies, and to accurately monitor infestation status in patients.

• Authors: S E Park, Y Her, S S Kim, C W Kim
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 40 Issue 6 Pg. 611-6 (Aug 2015) ISSN: 1365-2230 [Electronic] England
• PMID: 25807870 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 British Association of Dermatologists.

Chemical References

• Antiparasitic Agents
• Hexachlorocyclohexane

Topics

• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Antiparasitic Agents (adverse effects, therapeutic use)
• Dermoscopy (methods)
• Female
• Hexachlorocyclohexane (adverse effects, therapeutic use)
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Retrospective Studies
• Scabies (diagnosis, drug therapy)
• Sensitivity and Specificity