Abstract | BACKGROUND: METHODOLOGY AND PRINCIPAL FINDINGS: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non- cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. CONCLUSION: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.
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Authors | Feng-Yan Lin, Chiao-Wen Lin, Shun-Fa Yang, Wei-Jiunn Lee, Yung-Wei Lin, Liang-Ming Lee, Junn-Liang Chang, Wei-Chun Weng, Chien-Huang Lin, Ming-Hsien Chien |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 3
Pg. e0121677
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 25806809
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Alleles
- Areca
(adverse effects)
- Case-Control Studies
- Female
- Gene Frequency
(genetics)
- Gene-Environment Interaction
- Genetic Predisposition to Disease
(genetics)
- Haplotypes
(genetics)
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
(etiology, genetics, pathology)
- Polymorphism, Single Nucleotide
- Receptors, Melatonin
(genetics)
- Risk Factors
- Smoking
(adverse effects)
- Tobacco Use
(adverse effects)
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