18F-Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography in mucosa-associated lymphoid tissue lymphoma: variation in 18F-FDG avidity according to site involvement.

Abstract

The purpose of this study was to determine the 18F-FDG avidity of MALT lymphoma and the additional utility of 18F-FDG PET/CT in MALT lymphoma staging. Pretreatment 18F-FDG PET/CT scans of 222 patients with 227 MALT lymphoma lesions were retrospectively analyzed. 18F-FDG avidity of lesions was noted in 28%. The proportion was lower for gastric MALT lymphomas than for non-gastric lesions (9% vs. 60%, p<0.0001) and higher for mass-forming lesions than for superficial lesions (82% vs. 2%, p<0.0001). 18F-FDG PET/CT showed the presence of additional lesions in 23 patients: four of six true-positive lesions had 18F-FDG avid primary lesions, and 15 of 17 false-positive lesions had 18F-FDG-non avid lesions. 18F-FDG avidity differed according to the location and gross morphologic characteristics of the MALT lymphoma. Most gastric MALT lymphomas were superficial and had low 18F-FDG avidity. For staging, 18F-FDG PET/CT can be helpful mainly for 18F-FDG avid primary MALT lymphomas.

• Authors: Seol Hoon Park, Jong Jin Lee, Hye Ok Kim, Dong Yun Lee, Cheolwon Suh, Hwoon-Yong Jung, Kee Don Choi, Do Hoon Kim, Jooryung Huh, Jin-Sook Ryu
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 56 Issue 12 Pg. 3288-94 ( 2015) ISSN: 1029-2403 [Electronic] United States
• PMID: 25804932 (Publication Type: Journal Article)

Chemical References

• Fluorodeoxyglucose F18

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biopsy
• Endoscopy
• Female
• Fluorodeoxyglucose F18 (metabolism)
• Humans
• Lymphoma, B-Cell, Marginal Zone (diagnosis, metabolism, pathology)
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Neoplasm Staging
• Positron-Emission Tomography (methods)
• Retrospective Studies
• Tomography, X-Ray Computed (methods)
• Young Adult