Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study.

Abstract

A perioperative intravenous lidocaine infusion has been reported to decrease postoperative pain. The goal of this study was to evaluate the effectiveness of intravenous lidocaine in reducing postoperative pain for laparoscopic colectomy patients. Fifty-five patients scheduled for an elective laparoscopic colectomy were randomly assigned to 2 groups. Group L received an intravenous bolus injection of lidocaine 1.5 mg/kg before intubation, followed by 2 mg/kg/h continuous infusion during the operation. Group C received the same dosage of saline at the same time. Postoperative pain was assessed at 2, 4, 8, 12, 24, and 48 hours after surgery by using the visual analog scale (VAS). Fentanyl consumption by patient-controlled plus investigator-controlled rescue administration and the total number of button pushes were measured at 2, 4, 8, 12, 24, and 48 hours after surgery. In addition, C-reactive protein (CRP) levels were checked on the operation day and postoperative days 1, 2, 3, and 5. VAS scores were significantly lower in group L than group C until 24 hours after surgery. Fentanyl consumption was lower in group L than group C until 12 hours after surgery. Moreover, additional fentanyl injections and the total number of button pushes appeared to be lower in group L than group C (P < 0.05). The CRP level tended to be lower in group L than group C, especially on postoperative day 1 and 2 and appeared to be statistically significant. The satisfaction score was higher in group L than group C (P = 0.024). Intravenous lidocaine infusion during an operation reduces pain after a laparoscopic colectomy.

• Authors: EunJin Ahn, Hyun Kang, Geun Joo Choi, Yong Hee Park, So Young Yang, Beom Gyu Kim, Seung Won Choi
• Journal: International surgery (Int Surg) Vol. 100 Issue 3 Pg. 394-401 (Mar 2015) ISSN: 2520-2456 [Electronic] Italy
• PMID: 25785316 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Lidocaine

Topics

• Adult
• Aged
• Analgesics (therapeutic use)
• Colectomy (methods)
• Double-Blind Method
• Female
• Humans
• Infusions, Intravenous
• Injections, Intravenous
• Intraoperative Care (methods)
• Laparoscopy
• Lidocaine (therapeutic use)
• Male
• Middle Aged
• Pain, Postoperative (drug therapy, prevention & control)
• Preoperative Care (methods)
• Prospective Studies
• Treatment Outcome