Cyclic sulfoxides-garlicnins K1, K2, and H1-extracted from Allium sativum.

Abstract

Newly identified cyclic sulfoxides-garlicnins K1 (1), K2 (2), and H1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.

• Authors: Toshihiro Nohara, Yukio Fujiwara, Yusuke Komota, Yoshihiko Kondo, Taiki Saku, Koki Yamaguchi, Yoshihiro Komohara, Motohiro Takeya
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 63 Issue 2 Pg. 117-21 ( 2015) ISSN: 1347-5223 [Electronic] Japan
• PMID: 25748782 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• CD163 antigen
• Plant Extracts
• Receptors, Cell Surface
• Sulfoxides
• garlicnin H1
• garlicnin K1
• garlicnin K2

Topics

• Antigens, CD (analysis, metabolism)
• Antigens, Differentiation, Myelomonocytic (analysis, metabolism)
• Cell Line
• Enzyme-Linked Immunosorbent Assay
• Garlic (chemistry, metabolism)
• Humans
• Macrophages (cytology, drug effects, metabolism)
• Magnetic Resonance Spectroscopy
• Molecular Conformation
• Plant Extracts (chemistry)
• Plant Roots (chemistry, metabolism)
• Receptors, Cell Surface (analysis, metabolism)
• Sulfoxides (chemistry, isolation & purification, pharmacology)