[Functional biochemical changes and their pharmacologic correction by pirroksan in renal ischemia].

Abstract

Bilateral one-hour ischemia of the kidneys in rats causes essential metabolic shifts in the renal tissues, and diminished intensity of the energetic status as a result of which the intactness of the cell membranes and the main functions of the nephron are disturbed. Pharmacological correction of postischemic disorders by the alpha-adrenergic blocking agent pyrroxane increases the activity of oxidative processes and intensifies the glycolysis rate. Improvement of the energy provision of the nephron function occurs in parallel with restoration of the diuresis level and processes of filtration and reabsorption.

• Authors: V I Shepotinovskiĭ, Z I Mikashinovich, G A Shapiro, O V Ivanova
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1989 Jul-Aug Issue 4 Pg. 24-7 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Funktsional'no-biokhimicheskie izmeneniia i ikh farmakologicheskaia korrektsiia pirroksanom pri ishemii pochek.
• PMID: 2574439 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Dioxanes
• Dioxins
• Urea
• proroxan

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Animals
• Dioxanes (therapeutic use)
• Dioxins (therapeutic use)
• Diuresis (drug effects, physiology)
• Drug Evaluation, Preclinical
• Glomerular Filtration Rate (drug effects, physiology)
• Ischemia (drug therapy, enzymology, physiopathology)
• Kidney (blood supply, enzymology, physiopathology)
• Rats
• Time Factors
• Urea (metabolism)