Adalimumab-induced lupus serositis.

Abstract

A 61-year-old man presented with a 1-month history of breathlessness, chest pain and lethargy. He had been taking adalimumab for ankylosing spondylitis for 2 years. Pleural and pericardial effusions were both found. A video-assisted thorascopic (VATS) pleural and lung biopsy were performed. The pleural pathology showed eosinophils, acute inflammatory cells and lymphoid aggregates. The patient was positive for antinuclear, antidouble-stranded and antihistone antibodies consistent with drug-induced lupus due to adalimumab. His serositis resolved on withdrawal of the drug. Drug-induced lupus can occur as a consequence of anti-TNF-α agents from induction of autoimmunity in a predisposed host.

• Authors: Dearbhla Kelly, Oisin O'Connell, Michael Henry
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2015 (Mar 04 2015) ISSN: 1757-790X [Electronic] England
• PMID: 25739794 (Publication Type: Case Reports, Journal Article)
• Copyright: 2015 BMJ Publishing Group Ltd.

Chemical References

• Anti-Inflammatory Agents
• Adalimumab

Topics

• Adalimumab (adverse effects)
• Anti-Inflammatory Agents (adverse effects)
• Cardiomegaly (chemically induced)
• Humans
• Male
• Middle Aged
• Pericardial Effusion (chemically induced)
• Pleural Effusion (chemically induced)
• Serositis (chemically induced)
• Spondylitis, Ankylosing (drug therapy)
• Withholding Treatment