Efficacy of recombinant human interleukin 7 in a patient with severe lymphopenia-related progressive multifocal leukoencephalopathy.

Abstract

In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement.

• Authors: Jacques Gasnault, Marie-Ghislaine de Goër de Herve, Jean-Marie Michot, Houria Hendel-Chavez, Vannina Seta, Anne-Aurélie Mazet, Thérèse Croughs, Bruno Stankoff, Jean-Henri Bourhis, Olivier Lambotte, Jean-François Delfraissy, Yassine Taoufik
• Journal: Open forum infectious diseases (Open Forum Infect Dis) Vol. 1 Issue 2 Pg. ofu074 (Sep 2014) ISSN: 2328-8957 [Print] United States
• PMID: 25734144 (Publication Type: Journal Article)