The differences in clinicopathological features and prognosis among the subtypes of signet ring cell, mucinous, papillary, and lymphoepithelioma-like carcinoma in advanced gastric cancer.

Abstract

BACKGROUND/AIMS:

There are differing histologic subtypes of gastric cancer. We investigated the clinicopathological features and prognosis of: signet ring cell (SRC), mucinous (MGC), papillary (PGC), and lymphoepithelioma-like (LELC) carcinoma in advanced gastric cancer.

METHODOLOGY:

One hundred thirty six advanced gastric cancer patients, including 62 SRCs, 43 MGCs, 9 PGCs, and 22 LELCs, who underwent R0 gastrectomy between 2002 and 2013, were retrospectively evaluated.

RESULTS:

There were significant differences in several clinicopathological features. There were found to be statistical differences in postoperative outcomes in the type of gastrectomy and type of anastomosis (p<0.001 and p<0.001, respectively). In terms of overall survival analysis, there was no statistical survival difference among the subtypes of advanced gastric cancer (p=0.088). However, LELC had a better prognosis than the other groups.

CONCLUSIONS:

There were some differences in several of the clinicopathological features of the subtypes advanced gastric cancer. Although there were no statistical differences in survival, those with LELC showed a better prognosis than did the other groups. Therefore, the treatment of advanced gastric cancer should be individualized, and prognosis considered, according to the subtype.

• Authors: Ki-Han Kim, Min-Chan Kim, Ghap-Joong Jung, Su-Jin Kim
• Journal: Hepato-gastroenterology (Hepatogastroenterology) Vol. 61 Issue 135 Pg. 2149-55 (Oct 2014) ISSN: 0172-6390 [Print] Greece
• PMID: 25713922 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Anastomosis, Surgical
• Carcinoma, Papillary (pathology, secondary, surgery)
• Carcinoma, Signet Ring Cell (pathology, secondary, surgery)
• Female
• Gastrectomy
• Humans
• Lymphoma (pathology, surgery)
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Neoplasms, Cystic, Mucinous, and Serous (pathology, secondary, surgery)
• Retrospective Studies
• Stomach Neoplasms (pathology, surgery)
• Survival Analysis
• Time Factors
• Treatment Outcome