Abstract | PURPOSE: MATERIALS AND METHODS: This retrospective study was conducted on 84 LABC cases. Immunohistochemical expression of TOP2α and TIMP-1 was evaluated in pretreatment needle core biopsies. Results were correlated with clinicopathlogic parameters, response to neoadjuvant chemotherapy in postoperative specimens, disease-free survival and overall survival (OS). RESULTS: Positive TOP2α expression was detected in 57/84 (67.9%) cases. It was significantly associated with good response to chemotherapy in breast (P=0.048) and lymph node (P=0.06) as well as prolonged OS (P=0.04). It tended to be the most independent prognostic factor for OS (P=0.06). Positive TIMP-1 expression was detected in 48/84 (57.1%) cases. It was significantly associated with poor response to chemotherapy in breast (P=0.02). The 2T profile (TOP2α+ and TIMP-1-) was significantly associated with good response to chemotherapy in breast (P=0.006). CONCLUSION:
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Authors | Hala S El Rebey, Hayam A S Aiad, Iman L Abulkheir, Nancy Y Asaad, Moshira M A El-Wahed, Fatma M Abulkasem, Shereen F Mahmoud |
Journal | Applied immunohistochemistry & molecular morphology : AIMM
(Appl Immunohistochem Mol Morphol)
Vol. 24
Issue 3
Pg. 167-78
(Mar 2016)
ISSN: 1533-4058 [Electronic] United States |
PMID | 25710584
(Publication Type: Journal Article)
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Chemical References |
- Anthracyclines
- Antigens, Neoplasm
- DNA-Binding Proteins
- DNA Topoisomerases, Type II
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Topics |
- Anthracyclines
(therapeutic use)
- Antigens, Neoplasm
(metabolism)
- Breast Neoplasms
(drug therapy, enzymology, metabolism)
- Chemotherapy, Adjuvant
- DNA Topoisomerases, Type II
(metabolism)
- DNA-Binding Proteins
(metabolism)
- Egypt
- Female
- Humans
- Middle Aged
- Prognosis
- Survival Analysis
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