Effect of R-CHOP chemotherapy on liver and mediastinal blood pool (18)F-FDG standardized uptake values in patients with non-Hodgkin's lymphoma.

Abstract

AIM:

We aimed to investigate the impact of chemotherapy on (18)F-FDG uptake in the liver and mediastinal blood pool (MBP) among patients with non-Hodgkin's lymphoma.

METHODS:

Twenty-three patients with NHL underwent baseline, interim, and postchemotherapy (18)F-FDG PET/CT. SUVmax and SUVmean values of the liver and MBP at imaging time were compared statistically.

RESULTS:

We did not find any significant differences between the liver and mediastinum SUVmean and SUVmax values (P>.05).

CONCLUSIONS:

Our study demonstrates that the (18)F-FDG uptake in the liver and MBP are not significantly affected by R-CHOP chemotherapy in patients with NHL.

• Authors: Bugra Kaya, Zeki Dostbil, Murat Ismailoglu, Bekir Tasdemir, Ozlem Sahin
• Journal: Clinical imaging (Clin Imaging) 2015 Jul-Aug Vol. 39 Issue 4 Pg. 632-5 ISSN: 1873-4499 [Electronic] United States
• PMID: 25709112 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• R-CHOP protocol
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• Rituximab
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Aged
• Antibodies, Monoclonal, Murine-Derived (pharmacology, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
• Cyclophosphamide (pharmacology, therapeutic use)
• Doxorubicin (pharmacology, therapeutic use)
• Female
• Fluorodeoxyglucose F18
• Humans
• Liver (diagnostic imaging, drug effects)
• Lymphoma, Non-Hodgkin (diagnostic imaging, drug therapy)
• Male
• Mediastinum (diagnostic imaging)
• Middle Aged
• Positron-Emission Tomography (methods)
• Prednisone (pharmacology, therapeutic use)
• Radiopharmaceuticals
• Rituximab
• Vincristine (pharmacology, therapeutic use)