Abstract | INTRODUCTION AND HYPOTHESIS: The discovery of tension-free vaginal tape (TVT) began in 1986 with two unrelated observations: pressure applied unilaterally at the midurethra controlled urine loss on coughing; implanted Teflon tape caused a collagenous tissue reaction. METHODS AND RESULTS: In 1987, Mersilene tape was implanted retropubically in 13 large dogs, with the aim of creating an artificial collagenous pubourethral neoligament. Extensive testing showed that the operation was safe and effective. In 1988-1989, human testing was carried out (n = 30). Mersilene tape cured 100 % of stress and mixed incontinence with a sling in situ; however, there was simultaneous recurrence of the two symptoms in 50 % on sling removal. X-rays showed no elevation of the bladder neck. In 1990-1993, collaboration with Ulf Ulmsten took place: a permanently implanted tape was required. Polypropylene was the ideal material. In 2003, the neoligament principle was applied as an adjustable "micro" sling to the arcus tendineus fasciae pelvis ( ATFP), cardinal, uterosacral ligaments, and perineal body for cure of cystocele, rectocele, and apical prolapse. It was found that symptoms such as urgency, nocturia, chronic pelvic pain, obstructive defecation syndrome (ODS), and fecal incontinence were frequently cured or improved. CONCLUSIONS: The lecture concluded with advice to younger members. Without new paradigms, there are no randomized controlled trials, no meta-analyses, Cochrane. Indeed, no progress. Be open to new concepts. Read Kuhn's "The Structure of Scientific Revolutions" to understand the discovery process. Examine the relationship among symptoms, ATFP, cardinal, uterosacral ligaments, and the perineal body. This is the next paradigm. Don't disregard anomalies. Pursue them. They are the pathway to discovery. Innovation is born from challenge, not conformity. Persist, even when meeting resistance. Resistance is a sign that your discovery is important.
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Authors | Peter Petros |
Journal | International urogynecology journal
(Int Urogynecol J)
Vol. 26
Issue 4
Pg. 471-6
(Apr 2015)
ISSN: 1433-3023 [Electronic] England |
PMID | 25693655
(Publication Type: Historical Article, Journal Article, Lecture)
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Chemical References |
- Polyethylene Terephthalates
- Polypropylenes
- Lavsan
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Topics |
- Animals
- Dogs
- Female
- History, 20th Century
- History, 21st Century
- Humans
- Ligaments
- Models, Biological
- Polyethylene Terephthalates
- Polypropylenes
- Recurrence
- Suburethral Slings
(adverse effects, history)
- Urinary Incontinence, Stress
(history, surgery)
- Urinary Incontinence, Urge
(history, surgery)
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