Application of the European Society of Cardiology, Adult Treatment Panel III and American College of Cardiology/American Heart Association guidelines for cardiovascular risk management in a French cohort of rheumatoid arthritis.

Abstract

BACKGROUND:

Patients with rheumatoid arthritis (RA) have greater rates of cardiovascular mortality and RA is an independent cardiovascular risk factor. For the management of cholesterol, the American College of Cardiology/American Heart Association (ACC/AHA) developed new guidelines for the general population. None of the European or American guidelines are specific to RA. The European League Against Rheumatism (EULAR) recommends applying a coefficient to cardiovascular risk equations based on the characteristics of RA. Our objective was to compare the three different sets of guidelines for the eligibility of statin therapy in RA-specific population with very high risk of cardiovascular disease.

METHODS AND RESULTS:

We calculated the proportion of patients eligible for statins according to the guidelines of the European Society of Cardiology (ESC), the Adult Treatment Panel III (ATP-III) and the ACC/AHA in a French cohort of statin-naïve RA patients at least 40 years age. Of the 547 women and 130 men analyzed, statins would be recommended for 9.1% of the women and 26.4% of the men, 15.6% of the women and 53.1% of the men, 38.8% of the women and 78.5% of the men, according to the ESC, ATP-III and ACC/AHA guidelines respectively.

CONCLUSIONS:

In RA patients, as has been observed in the general population, discordance in risk assessment and cholesterol treatment was observed between the three sets of guidelines. The use of the new ACC/AHA guidelines would expand the eligibility for statins and may be applied to RA population a condition at very high risk of cardiovascular disease.

• Authors: Anne Tournadre, Zuzana Tatar, Bruno Pereira, Maxime Chevreau, Laure Gossec, Philippe Gaudin, Martin Soubrier, Maxime Dougados
• Journal: International journal of cardiology (Int J Cardiol) Vol. 183 Pg. 149-54 (Mar 15 2015) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 25666124 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015. Published by Elsevier Ireland Ltd.

Chemical References

• Amino Acids
• statine

Topics

• Adult
• Aged
• American Heart Association
• Amino Acids (therapeutic use)
• Arthritis, Rheumatoid (drug therapy, physiopathology)
• Cardiology (methods, standards)
• Cardiovascular Diseases (prevention & control)
• Cohort Studies
• Dyslipidemias (therapy)
• Female
• France
• Humans
• Male
• Middle Aged
• Practice Guidelines as Topic
• Risk Assessment
• Risk Factors
• Risk Management
• United States